Nitrosoxacins A, B and C, new 5-lipoxygenase inhibitors.
نویسندگان
چکیده
منابع مشابه
Nitrosoxacins A, B and C, new 5-lipoxygenase inhibitors.
this paper, we describe the production, isolation and structural studies of these new inhibitors. The producing strain was isolated from a soil sample collected in Kisarazu City, Chiba Prefecture, Japan, and taxonomic studies indicated that the strain belonged to the genus Streptomyces. This strain was fermented in 500-ml Erlenmeyer flasks in 100 ml of medium (soluble starch 2.5%, glucose 1 %, ...
متن کاملNew Insight into the SAR of Pyrimido [4,5-b][1,4] Benzothiazines as 15-lipoxygenase Inhibitors
Objective(s): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards FeIII-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide. In this paper the results of a comparative study on the SLO inhibitory activities of the ...
متن کاملEpocarbazolins A and B, novel 5-lipoxygenase inhibitors. Taxonomy, fermentation, isolation, structures and biological activities.
New 5-lipoxygenase inhibitors, designated epocarbazolins A and B, were isolated from the culture broth of Streptomyces anulatus T688-8. These compounds showed potent rat 5-lipoxygenase inhibitory activity with weak antibacterial activity. Structural studies revealed that epocarbazolins are new carbazole antibiotics having a novel substitution pattern and an epoxide in the side chain.
متن کاملnew insight into the sar of pyrimido [4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors
objective(s): recently we reported that the soybean 15-lipoxygenase (slo) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards feiii-oh in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide. in this paper the results of a comparative study on the slo inhibitory activities of the me...
متن کاملDesign and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors
Objective(s): 15-Lipoxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inflammations, sensitivities, and some cancers has been demonstrated in mammals. The importance of enzymes has led to the development of mechanistic studies, product analysis, and synthesis of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1993
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.46.193